Fluorine Synthetic and Medicinal Research Group
Resarch
Metathesis chemistry
New catalysts and methods in the field of stereoselective metathesis are vital in view of the pharmaceutical and material applications. We have developed new methods to make stereodefined alkenes with a fluro-chloro terminus as a uniquely enabling compound class using molybdenum catalysts. And also molybdenum catalyzed stereoselective synthesis of trifluoromethyl alkene was developed, which can serve as a useful tool to make trisubstituted trifluoromethyl alkenes and their derivatives.
Fluorine chemistry
We are also interested of new reagents and methods for the preparation of potentially useful chiral fluorine-containing scaffolds, adn further insight into the mechanism of these chemistries. We have developed several new sulfur-containing reagents, which have important applications for stereoselective fluorination, fluoroolefination and fluoroalkylation.